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PUBLICATIONS: Lu Rao

2022

Impastato A. C., A. Shemet, N. A. Vepek, G. Saper, H. Hess, L. Rao, A. Gennerich, D. Trauner. Optical Control of Mitosis with a Photoswitchable Eg5 Inhibitor. 2022. Angew Chem Int Ed Engl. 61:e202115846. [pdf]

2021

Lam A. J., L. Rao, Y. Anazawa, K. Okada, K. Chiba, M. Dacy, S. Niwa, A. Gennerich, D. W. Nowakowski, R. J. McKenney. A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health. 2021. Sci Adv. 7:eabf1002. [pdf]

Boyle, L., L. Rao, S. Kaur, X. Fan, C. Mebane, L. Hamm, A. Thornton, J. T. Ahrendsen, M. P. Anderson, J. Christodoulou, A. Gennerich, Y. Shen, W. K. Chung. Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder. 2021. HGG Adv. 2:100026. [pdf]

Budaitis, B. G.*, S. Jariwala*, L. Rao*, Y. Yue, D. Sept#, K. J. Verhey#, and A. Gennerich#. Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms. 2021. J. Cell Biol. 220:e202004227 (*: co-first authors listed alphabetically; #: corresponding authors). [pdf]

2020

Liu, X., L. Rao, and A. Gennerich. The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein. 2020. Nat. Commun. 11:5952. [pdf]

Brenner, S., F. Berger, L. Rao, M. P. Nicholas, and A. Gennerich. Force production of human cytoplasmic dynein is limited by its processivity. 2020. Sci. Adv. 6:eaaz4295. [pdf]

2019

Rao, L., F. Berger, M. P. Nicholas, and A. Gennerich. Molecular mechanism of cytoplasmic dynein tension sensing. 2019. Nat. Commun. 10:3332. [pdf]

2018

Rao, L., M. Hülsemann, and A. Gennerich. Combining structure-function and single-molecule studies on cytoplasmic dynein. 2018. Methods Mol. Biol., 1665:53-89. [pdf]

2015

Nicholas, M. P., F. Berger, L. Rao, S. Brenner, C. Cho, and A. Gennerich. Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains. 2015. Proc. Natl. Acad. Sci. USA, 12:6371-6376. [pdf]

2014

Nicholas, M. P., L. Rao, and A. Gennerich. Covalent immobilization of microtubules on glass surfaces for molecular motor force measurements and other single-molecule assays. 2014. Methods Mol. Biol., 1136:137-169. [pdf]

Nicholas, M. P., L. Rao, and A. Gennerich. An improved optical tweezers assay for measuring the force generation of single kinesin molecules. 2014. Methods Mol. Biol., 1136:171-246. [pdf]

2013

Rao, L.*, E. M. Romes*, M. P. Nicholas, S. Brenner, T. Ashutosh, A. Gennerich#, and K. C. Slep#. The yeast dynein dyn2-pac11 complex is a dynein dimerization/processivity factor: structural and single molecule characterization. 2013. Mol. Biol. Cell, 24:2362-2377 (*: co-first authors; #: co-corresponding authors). [pdf]

2011

Rao, L., J. D. Dworkin, W. E. Nell, and U. Bierbach. Interactions of a platinum-modified perylene derivative with the human telomeric g-quadruplex. 2011. J. Phys. Chem. B. 115:13701-13712. [pdf]

Choudhury, J. R., L. Rao, and U. Bierbach. Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay. 2011. J. Biol. Inorg. Chem. 16:373-380. [pdf]

2010

Rao, L., T. West, G. Saluta, G. Kucera, and U. Bierbach. Probing platinum-adenine-N3 adduct formation with DNA minor-groove binding agents. 2010. Chem. Res. Toxicol. 23:1148-1150. [pdf]

2009

Ma, Z., L. Rao, and U. Bierbach. Replacement of a thiourea-S with an amidine-NH donor group in a platinum-acridine antitumor compound reduces the metal's reactivity with cysteine sulfur. 2009. J. Med. Chem. 52:3424-3427. [pdf]

2007

Rao, L., and U. Bierbach. Kinetically favored platination of adenine in the G-rich human telomeric repeat. 2007. J. Am. Chem. Soc. 129:15764-15765. [pdf]